The Black & Gold have been looking for a way to start a run of results and the team earned its first back-to-back victory, after Sunday's 3-1 performance, since late April.
It was a very fast start for Columbus, who were awarded a penalty kick just 12 seconds into the match.
Forward Kei Kamara headed down a long pass off the kickoff right into the run of winger Ethan Finlay. The midfielder went one v. one with Chicago goalkeeper Sean Johnson and was taken down in the 18-yard box.
Federico Higuain stepped up to the spot and gave Crew SC the 1-0 lead after just two minutes.
The Fire didn't accept going down early and looked to attack.
After nine minutes, the Men in Red were rewarded when David Accam fired a free kick off the Black & Gold wall that beat goalkeeper Steve Clark to pull the match level.
Crew SC didn't take long to get the lead back, as eight minutes later, Major League Soccer's league leading goal scorer bagged his 14th of the season.
Once again it was the athletic ability of Kamara that earned him the finish, as he rose above Johnson to head home a lofted cross from Waylon Francis.
Shortly before halftime, another Accam free kick caused Columbus issues again. This time the set piece was crossed in and found the head of forward Jason Johnson in a good position. His effort went just wide.
Just before the break, midfielder Justin Meram almost gave Columbus a third goal on a header, but it went narrowly over the crossbar.
Things went from bad to worse for Chicago five minutes into the second half when Johnson was given a second yellow card for embellishing. Defender Tyson Wahl did make slight contact with the forward, but Johnson made a meal of it and center referee Chris Penso sent him for an early shower.
Finlay finished things off in the 83rd minute with his sixth goal of the season.
After a cross from right back Chad Barson squeaked through the Fire's back line, Finlay was on the back post for the finish that Johnson nearly saved.
Crew SC will look to ride the momentum next weekend when the club welcomes Toronto FC to MAPFRE Stadium.